Fersht A, 1999

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Fersht A, 1999

Fersht gives a complete set of pK values in his 1999 book Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding (1). The pK values given are from model compounds (small peptides) reported in Tanford (1962), Tanford and Roxby (1972) or Shaked, Szajewski and Whitesides (1980) (2-4).

Amino acid pK values from Fersht A, 1999 (1).

Group

pK

CT

3.6

†

ASP

4.0

†

GLU

4.5

†

HIS

6.4

†

NT

7.8

†

CYS

9.1

†

TYR

9.7

†

LYS

10.4

†

ARG

12

†‡

† Data from Table 5.1.

‡ The value is reported as ~12 in Table 5.1.

References

(1) Fersht A (1999) Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding W H Freeman, New York

(2) Tanford C (1962) Advances in protein chemistry, Academic Press, New York.

(3) Tanford C & Roxby R (1972) Interpretation of protein titration curves. Application to lysozyme. Biochem 11:2192-8.

(4) Shaked Z, Szajewski RP & Whitesides GM (1980) Rates of thiol-disulfide interchange reactions involving proteins and kinetic measurements of thiol pKa values. Biochem 19:4156-66.